Michigan and Wisconsion residents who recently returned from northern Germany is among four people in the U.S. apparently sickened by a severe E. coli outbreak that has killed 22 people in Europe, state health officiasl said.

The U.S. Centers for Disease Control and Prevention announced Friday that three of the four had been hospitalized with kidney failure, a hallmark of the E. coli outbreak that has sickened more than 2,200 people.

The person from Michigan is recovering in the southeastern portion of the state, Department of Community Health spokeswoman Kelly Niebel told The Detroit News for a story published Monday.